Cat B 680 FAST Fluorescent Imaging Agent | PerkinElmer

幸运8平台彩票

PerkinElmer
check quantity

Cat B 680 FAST Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.  

部件号 NEV11112
立即购买

请输入有效的数量

幸运8平台彩票 请登录后再添加至收藏夹

购物车为空

项目已成功添加到购物车

For laboratory use only. This product is intended for animal research only and not for use in humans.

详情 信息

幸运8平台彩票Cat B 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background. 

Cat B 680 FAST is a Cathepsin B activatable fluorescent agent that is optically silent upon injection and produces fluorescent signal after cleavage by Cathepsin B produced by inflammatory cells and tumor cells. Cat B 680 FAST may be used to monitor inflammation, tumor activity, progression of disease and the efficacy of therapeutic treatment in applications such as oncology, inflammation, cardiovascular disease and some neurological diseases.

规格

荧光剂类型 Activatable
光学成像分类 Fluorescence Imaging
产品品牌名称 Cat B FAST
包装量 1.0 Units
运输条件 环境
治疗领域 Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer
产品尺寸 1 Vial (10 doses)
波长 680 nm
资源,活动及更多信息
  • 所有

Citations Library

链接

网络研讨会

链接

网络研讨会

产品手册

单页

应用文献

In Vivo Imaging of Atherosclerosis Disease Using FMT

Current means of measuring disease in preclinical models of atherosclerosis include ex vivo assessment of disease tissues post-mortem and non-invasive imaging primarily of structural and anatomic features of lesions, in vivo. A non-invasive, quantitative means of imaging known biologic profiles associated with atherosclerotic disease, in vivo, would enable a robust additional understanding and analysis of disease progression and therapeutic response in research and drug development. We report the utility of the near infrared (NIR) protease-sensing, ProSense® 750 Fluorescent Pre-clinical Imaging Agent, in combination with the FMT® 2500 Quantitative Pre-clinical Imaging System for the non-invasive quantitative measurement of atherosclerotic disease biology and related response to therapy in apolipoprotein (apo) E-deficient mice in vivo. FMT (Fluorescence Molecular Tomography) imaging measured significant increases in aortic region protease activity with a range of values that were comparable to the range seen in the ex vivo aortic arches assessed by fluorescence reflectance imaging (FRI).

PDF 1 MB

技术说明

Cat B 680 FAST (Protocol)

Cat B™ 680 FAST ( NEV11112) IN VIVO IMAGING PROTOCOL ,

PDF 252 KB
Cat B 680 FAST™ (Data Sheet)

Cat B 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points.

PDF 192 KB

海报

A novel NIR dye for in vivo temporal tracking of labeled macrophages to sites of acute inflammation

幸运8平台彩票A novel NIR dye for in vivo temporal tracking of labeled macrophages to sites of acute inflammation

PDF 689 KB
Non-Invasive Quantitative Tomography of Disease Progression and Therapeutic Response

We have demonstrated the ability of our Fluorescence Tomography (FMT 2500) in vivo imaging system and ProSense 680 to non-invasively visualize and quantify inflammation in the lung in a robust and validated manner. The consistency of the quantitative tomography, as well as its excellent correlation with BAL assessment of eosinophilia, provide a powerful toolkit for quantifying the therapeutic efficacy of dexamethasone treatment. Utilizing new and existing imaging agents, FMT imaging in asthma research provides useful, non-invasive tools for understanding pulmonary inflammation and for developing new therapeutics in vivo.

PDF 581 KB