AxION 2 TOF MS | PerkinElmer

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AxION 2 飞行时间质谱

AxION® 2 TOF MS 提供简化的分析流程,让您能够轻松获得最佳的结果。

部件号 MZ320025
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For research use only. Not for use in diagnostic procedures.

详情 信息

主要特性:

  • 精确的质量分析性能和超宽的动态线形范围,是化合物的鉴别和定量的最有利工具
  • 可调双探头离子源可以微调以优化灵敏度,并可实现高级内部校准液的同时喷雾
  • 获得专利的捕获和脉冲技术使灵敏度增加了3-5倍
  • V形飞行路线能达到最大的离子透过率,灵敏度出众
  • 采集速率高,能进行快速色谱分析
  • 针对具体的应用和工作流程,选择定制的软件包

优质光谱的创新源
专利捕获和脉冲技术——在加速进入飞行管之前,通过收集密集的离子束,尽可能提高灵敏度。脉冲器的工作循环与离子束的到达完美同步,确保离子最大程度地传输到最新型的检测器。创新高效的捕获和脉冲技术能够提供较高强度的信号,并降低基线噪音,同时在飞行时间MS采集的过程中保持出色的分辨率和质量测量精度。

为了增加灵活性,AxION2 TOF MS提供多种可选的专利离子源,用于在任何分析条件下系统性能的优化:
幸运8平台彩票 UltrasprayTM2——独特的可调双探头电喷雾离子(ESI)源,使您能够优化离子源探头的角度,达到最佳的灵敏度。其设计还让您为样品专门指定一个离子源探头进口,而另一个进口则专供内标使用。这样通过进行实时校准,您就可以避免样品探头的污染,达到最高的质量精度——而不会影响灵敏度或分辨率。大气压化学电离(APCI)源——即使在流速非常低的情况下,开创性的场屏蔽APCI源能够提供最高的离子化效率(以及灵敏度),让您能够轻松获得最佳的结果,同时减少样品和溶剂的使用量。

规格

21 CFR Part 11兼容 Yes
最高温度 26 °C
最低温度 16 °C
便携式 No
产品品牌名称 AxION
技术类型 Mass Spectrometry
保修 1 year
资源,活动及更多信息
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产品手册

AxION 2 TOF Brochure

幸运8平台彩票The AxION 2 TOF MS offers a broad array of capabilities designed to simplify and streamline virtually any analytical workflow. Whether your application places an emphasis on the instrument’s mass accuracy, full spectrum capability, speed, sensitivity,dynamic range, or all of the above, the AxION 2 TOF MS delivers exactly what you need to achieve confident, accurate results.

PDF 2 MB
AxION Solo/Xpo Call Out Sheet

Designed for optimal flexibility and productivity, AxION® Solo™ streamlines the most complex LC/MS analyses by allowing you to define your own criteria and processing methods to find one or many substances by mass or formula. An intensity-driven heat mapping and graphical user interface provides superior visualization of results for quick interpretation and reporting. Whether you’re searching for single or multiple targets, AxION Solo allows you to take the fast, easy way to clear, confident analytical results.

PDF 295 KB

单页

AxION eDoor SQ Flyer

幸运8平台彩票From running an individual sample to managing a complete network of instruments and users, AxION® eDoor™ has the power to simplify every aspect of your laboratory operation. A robust yet intuitive open-access software, eDoor works with the Flexar™ SQ 300 MS to deliver reliable, high quality MS results no matter how complex your samples or workflows.

PDF 642 KB

应用文献

A Quantitative SLE LC TOF MS Method to Detect Multiple Drugs in Urine

Liquid chromatography-mass spectrometry (LC/MS) is commonly used to measure drugs and their concentrations in extracts of biological matrices. Triple quadrupole MS is often employed for targeted quantitative analysis, using multiple reaction monitoring (MRM) mode. Here, the intensity of product ions resulting from the collisionally induced fragmentation of a specified precursor ion is measured. Using MRM mode requires complex method optimization for each compound and the measurement is limited to targeted species. In contrast, time-of-flight (TOF) MS has higher mass resolution than quadrupole MS and allows for post-acquisition data interrogation of drugs and metabolites not originally specified in the experimental method. This latter process is not possible using triple quadrupole MRM data, which only records information on those species originally specified. This study was conducted to evaluate the performance of a quantitative LC/TOF MS method to detect 52 drugs and drug metabolites in human urine.

PDF 1 MB
Analysis of Cathinones in Bath Salts by Direct Sample Analysis TOF MS

幸运8平台彩票There is no standard method to quickly screen and confirm cathinones in bath salts. To address this issue, use of the AxION® Direct Sample Analysis™ (DSA™) integrated with the AxION 2 time-of-flight,mass spectrometer (TOF) (PerkinElmer, Waltham, MA) was implemented. Cathinone standards and bath salt samples were rapidly screened and confirmed in seconds by accurate mass and isotopic distribution of parent and fragment ions using DSA/TOF and AxION Solo™ software.

PDF 2 MB
Analysis of Pharmaceutical and Personal Care Products in River Water Samples by UHPLC-TOF

We present a study of PPCPs in river water samples from the northeastern United States using UHPLC-TOF-MS for both targeted and non-targeted analytes. Unlike a triple quadrupole, which is operated in multiple reaction monitoring mode for screening only predefined targeted analytes, the time-of-flight (TOF) mass,spectrometer provides full spectrum accurate mass data that can be used to analyze and identify an unlimited number of compounds, without prior knowledge of target analytes or when reference standards are not available. In this study we show how high mass accuracy information provided by the PerkinElmer,AxION 2® TOF along with the priopriatory AxION EC ID software can be used to identify unknown analytes in surface river waters.

PDF 951 KB
Analysis of Quaternary Ammonium Compounds (QACs) as Possible Disinfectant Residues in Milk by LC-TOF

幸运8平台彩票Quaternary ammonium compounds (QACs) have the basic structure NR4. Those possessing R groups with long alkyl chains are known to be especially effective as antimicrobial agents and particularly useful for the disinfection of containers and surfaces.

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Automated Direct Sample Analysis (DSA/TOF) for the Rapid Screening and Confirmation of Illicit Street Drugs

Screening methods for drugs of abuse,currently require long chromatographic,methods and sample preparation or,immunoassay techniques (EMIT) with,confirmation by GC/MS or LC/MS/MS.

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Differentiation of Cultivars of Spanish Olive Oils Using Multiple LC/MS Analysis Methods

The patterns of organic components in olive oils relate to the geographic origin, cultivar and processing methods for the olives. In this study a statistical analysis of the chemical components of authentic monovariatal virgin olive oils from Spain was used to determine markers for the cultivars. These markers could be used to confirm the provenance and origins of olive oil samples. Different LC/MS methods were used to measure the levels of a large number of polar and non-polar organic components in the oils. Results from the separate analyses were combined with data fusion. A statistical comparison with the combined results improved the discrimination of cultivar groups, when compared to a single LC/MS analytical method.

PDF 348 KB
Differentiation of Olive Varieties by the Triacylglyceride Levels of Oils –Statistical Analysis of LC/MS Results

Olives of different cultivars are used to produce oils with different particular flavors and stability. Oils of known cultivars from designated areas may be certified for authenticity, and are marketed internationally, commanding a price premium. This study reports on the measurement of the triacylglyceride composition of a large number of olive oils from known origins using a simple LC/MS method, together with statistical analysis of the results to find indicators for different cultivars. Such marker compounds could be used to test the authenticity of an unknown sample.

PDF 1 MB
Differentiation of Olive, Vegetable and Seed Oils by LC/MS Analysis of Triacylglycerides

Extra virgin olive oil has been adulterated throughout history with less expensive oils such as soybean or hazelnut oil. Detecting adulteration is important for maintaining both the safety and consumer confidence of this product. This study reports on the measurement of the triacylglyceride composition of a large number of olive oils and other seed and vegetable oils using a simple LC/MS method, together with statistical analysis of the results to find indicators for different oil types.

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Identification of Unanticipated Prescription Drugs and Metabolites in Donor Urine Using Accurate Mass LC/MS

幸运8平台彩票LC/MS analysis showed that a number of non-endogenous compounds were detected in this urine.

PDF 571 KB
LC/TOF MS Analysis of Phosphodiesterase Type 5 Inhibitors Extracted from Herbal Preparations

幸运8平台彩票Dietary supplement use is becoming more prevalent among adults. With this increased use there has been a concomitant rise in dietary supplement adulteration.

PDF 740 KB
Markers for Spanish Olive Oil Cultivars – Statistical Analysis of Polar Compounds from LC/MS Results

Polar components such as phenolic acids and lignans are present in olive oils. Secoiridoids; phenolics which include an elenolic acid moiety, are unique to the Olearaceae family. These compounds are known to have beneficial health effects due to their antioxidant properties and are associated with the organoleptic properties. Measuring the levels of these polar components in oils from different cultivars and geographic origins is of interest for nutritional and authenticity reasons. In this study a statistical analysis of the polar chemical components of olive oils was used to determine potential markers for olive cultivars. These markers could be used to confirm the provenance of unknown samples.

PDF 697 KB
Meeting EU REACH Requirements using Chemical Ionization Gas Chromatography/Mass Spectrometry

In this application note we describe how gas chromatography/mass spectrometry (GC/MS) utilizing the chemical ionization (CI) technique can help characterize chemicals for REACH registration and,compliance. The positive identification of 4,4’-Methylenebis(2,6-di-tert-butylphenol)1, common name Ethyl 702, is described. Improved analytical results are obtained using a mass flow controller (MFC) to,regulate the CI reagent gas flow. The mass flow control approach is described as is the Continuum mode data collection ability of the PerkinElmer TurboMass™ GC/MS software.

PDF 1 MB
Milk Adulteration with Melamine - Screening, Testing and Real-Time Detection

This work highlights that screening, testing or real-time detection can be utilized to detect melamine-adulterated milk in a supply chain and that by determining where the sampling is taking place, who is carrying out the measurement and whether the testing is to meet regulation, will define which technology to use.

PDF 1 MB
Quantification of Benzodiazepines in Plasma Using UHPLC Time-of-flight Mass Spectrometry

Presented is an alternative technique to quantitate benzodiazepines in plasma using a rapid protein precipitation method with a fast LC separation method in combination with TOF-MS.

PDF 1 MB
Quantitation of Dyes in Forensic Fibers Using UHPLC-TOF MS and Building a Dye Database with AxION EC ID Software

Fibers originating from textiles in carpet, furniture, and clothing are often used as evidence at crime scenes. Fiber analysis is traditionally performed using various non-destructive techniques including optical microscopy, visible and infrared micro-spectrophotometry. Chromatography techniques such as poor resolving thin-layer chromatography or higher resolution HPLC with UV or diode array detection (DAD) can also be used for fiber identification. In this study, we show analysis of dyes extracted from fibers using UHPLC coupled to time-of-flight mass spectrometry (TOF MS), providing a more specific and sensitive technique. TOF MS provides a higher degree of discrimination between closely resembling dyes with similar functional groups of detection compared to UV or DAD detection using accurate mass measurements and isotope ratio confirmations. We also provide a method to build a database for forensic dyes using accurate mass and isotope profile information acquired from the time-of-flight (TOF) mass spectrometer along with the proprietary AxION® EC ID™ software.

PDF 1 MB
Quantitative Analysis of Analytes in Urine using UHPLC Coupled to Accurate Mass AxION 2 TOF Mass Spectrometer

The PerkinElmer AxION® Time of Flight (TOF), fitted with ADC detector technology, provides a wide dynamic range and is suitable for quantitative analysis of target along with qualitative screening of unknown compounds. In this application note we present a workflow for the testing and quantification of compounds in urine. The accurate mass and isotope ratios provided by the AxION 2 TOF MS along with retention time matching is used to identify and confirm the presence of both known and unknown target analytes without the need for fragmentation information.

PDF 1 MB
Rapid Analysis of Apple Juice Adulteration with Pear Juice Using LC/TOF

Adulteration of fruit juices is quite common in the market place and is often done through juice substitution. Pear juice has a slightly lower market value than apple juice yet both have similarities in major chemical composition, making pear juice an ideal adulterant for apple juice. Both juices have similar carbohydrate, organic acid and amino acid levels, therefore the detection of apple juice adulteration with pear juice, based on these compounds, has limited applicability.

PDF 1 MB
Rapid Detection of Vanilla Bean Extract Adulteration with Tonka Bean Extract with No Chromatography or Sample Preparation

A variety of analytical techniques such as GC/MS, LC/MS, LC/UV, headspace GC/MS and stable isotope ratio analysis have been used to characterize vanilla bean extracts and detect its adulteration3-6. These measurement techniques are either expensive, time consuming, or both, and require extensive method development and sample preparation. In this work, we demonstrated that the AxION® Direct Sample Analysis™ (DSA™) system integrated with the AxION® 2 Time-of-Flight (TOF) mass spectrometer (DSA/TOF) can be used to detect contamination of vanilla bean extracts with tonka bean extracts with no chromatography or sample preparation, and within a few seconds.,

PDF 1 MB
Rapid Measurement of Olive Adulteration with Seed Oil

Olive oil and other oils are composed mainly of triacylglycerols. These molecules are derived from the esterification of three fatty acid molecules with a glycerol molecule. The main triglyceride in olive oil is triolein (OOO); whereas the main triglyceride in seed oils (soybean, corn and sunflower) is trilinolein (LLL). Therefore, the measurement of ratio of trilinolein to triolein in olive oil can be used as a way to detect its adulteration with soybean and other seed oils, such as corn and sunflower, which have a higher content of trilinolein and lower amount of triolein in comparison to olive oil3. Using this strategy with a Direct Sample Analysis™ Time-of-Flight mass spectrometry system (DSA/TOF), we detected adulteration of olive oil with soybean and corn oil. In the past, methods employing gas chromatography/mass spectrometry (GC/MS) and high performance liquid chromatography (HPLC) hyphenated to MS (HPLC/MS) were implemented for this purpose.,

PDF 1 MB
Rapid Screening of Adulteration in Pomegranate Juice with Apple Juice Using DSA/TOF with Minimal Sample Preparation

Pomegranate juice is in high demand due to its well documented health benefits. Studies based on a significant body of scientific research conducted on authentic pomegranate juice have,established that pomegranate juice has superior antioxidant activity compared to other popular fruit juices such as grape, orange and apple1,2,3. These superior health benefits have led to a meteoric rise in the popularity of pomegranate juice over the last 10 years. This has resulted in pomegranate juice having a significantly higher cost than other juices, especially in comparison to apple, orange and grape juice.

PDF 1 MB
STREAMLINE AND SIMPLIFY YOUR FORENSICS WORKFLOW

This reference notebook offers a diverse mix of forensic applications that specifically highlight the unique performance characteristics of the AxION 2 TOF and AxION DSA. Learn how our techniques and technology can screen, confirm and quantify various known and unknown sample types across a wide range of forensic and research applications.

PDF 4 MB
Testing and Quantification of Opioids in Serum by UHPLC-TOF

Testing of opioids is most commonly done using the Enzyme Multiple immunoassay Test (EMIT). Immunoassays suffer from non-specificity as they can only identify a class of drugs and cannot identify the specific compound within the class. As an example an immunoassay SAMHSA panel screens for opiates such as codeine and morphine but would not detect opioids such as oxycodone, which is a semi synthetic compound. This lack of specificity can lead to false positive or false negative results, needing confirmation by techniques such as GC/MS.

PDF 2 MB
Testing and Quantification of Opioids in Urine by UHPLC-TOF

幸运8平台彩票We present a study for screening of opioids along with the quantitation of the drugs in urine using a time-of-flight (TOF) mass spectrometer (MS) for use in forensic laboratories.

PDF 1 MB
UHPLC-TOF分析河水样品中的药物及个人护理产品

本研究证明了PerkinElmer AxION 2®TOF能够提供准确质量信息,且当其与AxION EC ID软件联用时,可用于鉴定地表水中的未知化合物。

PDF 1 MB
UHPLC与AxION 2TOF质谱联用快速定量分析橙汁中多菌灵

本文建立了一个少于5min稀释-上样的LC-TOF方法, 用于定量测定橙汁中的多菌灵。 结果表明该方法快速、 高效,样品通量可与那些已公开的方法相媲美,甚至更优。

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Whisky Origins Profiled By Data Fusion of LC/MS and ICP-MS Results Using TIBCO Spotfire Software

This study used TIBCO Spotfire® statistical analysis to investigate whether whisky compound profiles are specific to regional origins. Malt whiskies contain a large number of compounds, which vary according to the local ingredients, fermentation, distillation and maturation processes.

PDF 2 MB
Workflow for Quantification of Benzodiazepines in Urine Using UHPLC- TOF

We present an alternative technique to quantitate benzodiazepines in urine utilizing a rapid dilute and shoot LC method in combination with time-of-flight mass spectrometry (TOF MS).

PDF 1 MB
中药材违禁色素的快速检测

本文利用PerkinElmer公司的直接进样系统(DSA-TOF, Direct Sample Analysis-Time ofFlight) 建立了快速检测黄柏中非法添加金胺O的方法。

PDF 1 MB
使用LC/TOF MS分析中药制剂提取液中的5型磷酸二酯酶抑制剂

幸运8平台彩票本文使用LC/TOF MS方法进行膳食补充剂中PDE-5抑制剂掺假的筛查检测,该方法样品制备过程简单,液相色谱分离使得中药基质中的添加物都得到了很好的分离。

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利用AxION 2 TOFMS的精确质量、灵敏度和宽的动态范围进行杂质鉴

利用PerkinElmer Flexar FX-10 HPLC与AxION 2 TOF MS联用仪, 及创新的后处理软件组成的AxION平台, 可提高和简化杂质分析。 该分析快速、 简便和准确。

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利用Flesar SQ MS 与AxION DSA/TOF技术对柑橘类水果采摘后使用的杀菌剂进行快速筛查及定量分析

幸运8平台彩票本应用文献首次采用DSA/TOF技术对普通水果和有机水果中的杀菌剂进行快速筛查,每个样品均在10s内分析完成。结果显示,在五种普通的水果样品中均含有杀菌剂,一种有机水果样品中也含有杀菌剂。

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利用TOF MS直接进样方式分析浴盐中卡西酮类化合物

本应用文献建立了采用TOF MS直接进样方式分析浴盐中卡西酮类化合物的方法。

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利用UHPLC-TOF及高通量筛选软件针对性的筛查生菜叶QuEChERS法提取液中130种农残

本文建立了一种生菜叶中农残分析的方法,生菜叶使用QuEChERS法进行提取(快速、简单、便宜、高效、耐用和安全)。

PDF 1 MB
利用UHPLC与精确质量的AxION2 TOF质谱仪联用分析尿液中的滥用药物

本应用文献建立了21种滥用药物的分析方法,该方法在仪器提供的易于定量和报告的软件包的帮助下,可容易的被应用到更广泛的滥用药物筛查中。

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利用直接样品分析(DSA)时间飞行质谱仪分析可生物降解聚合物中的添加剂

幸运8平台彩票本项研究的目的是使用大气压离子化质谱仪快速的鉴定不同种类可生物降解聚合物中的多种添加剂。

PDF 993 KB
无需样品制备,使用DSA/TOF快速筛查用葡萄汁掺假的石榴汁

幸运8平台彩票在本应用文献中,我们建立了使用AxION®直接样品分析(DSA™) 系统结合AxION 2飞行时间(TOF) 质谱仪快速筛查用葡萄汁掺假的石榴汁, 无需样品制备。

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无需色谱分离及样品制备采用AxION DSA/TOF快速鉴别天然与人造香草素

本应用文献表明AxION®直接进样分析系统(DSA™)与AxION时间飞行(TOF)质谱仪联用技术可用于快速区别人工合成和天然香草提取物,且无需色谱分离和样品制备,几秒钟内就能完成。

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无需色谱分离或样品制备,快速测定香荚兰豆提取物中掺杂的零陵香豆提取物

在本应用文献中,建立了AxION直接样品分析系统(DSA™)与AxION® 2时间飞行(TOF)质谱联用仪(DSA/TOF)联用的检测方法,该方法无需色谱分离或者样品制备,在几秒钟内就可测定香荚兰豆提取物中掺杂的零陵香豆提取物。

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石榴汁掺假的检测

幸运8平台彩票本研究表明, 使用DSA/MS检测技术和紫外-可见光谱筛查技术, 检查果汁质量不再困难、 耗时和昂贵。

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自动直接样品分析(DSA/TOF)系统快速筛查和确证非法街售药物

本文采用AxION DSA/TOF提供了一种新的筛查非法药品的方法,与冗长的样品制备和色谱运行比较,该方法仅需几秒钟。通过AxION Solo软件根据母离子单一同位素质量、母离子同位素比、多个碎片离子的精确质量、碎片离子的同位素比进行生物样品中未知药物和滥用药物的筛查和确认,几秒钟内就可完成。

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采用DSA-TOF直接分析纳米金材料表面有机配体

幸运8平台彩票DSA-TOFMS提供了一种快速分析技术,在没有任何样品制备设备前提下分析有机纳米粒子。

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采用DSA/TOF技术进行橄榄油中掺杂的大豆油的快速检测

在本应用文献中,我们利用AxION直接样品分析(DSA™) 系统与AxION 2飞行时间(TOF) 质谱仪的联用技术, 建立了一种橄榄油中掺杂大豆油快速筛查的方法。

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采用最少的样品制备,利用DSA/TOF快速筛查掺杂了苹果汁的石榴汁

建立了使用AxION®直接样品分析(DSA™) 系统与AxION 2时间飞行(TOF) 质谱仪联用的方法, 采用最小的样品制备, 根据稳定的同位素稀释, 快速测定苹果汁掺假的石榴汁。

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技术说明

AxION 2 TOF MS

幸运8平台彩票AxION 2 TOF MS Product Note

PDF 1 MB
AxION 2 TOF TrapPulse TechNote

幸运8平台彩票Designed for optimal flexibility and productivity, AxION® Solo™ streamlines the most complex LC/MS analyses by allowing you to define your own criteria and processing methods to find one or many substances by mass or formula. An intensity-driven heat mapping and graphical user interface provides superior visualization of results for quick interpretation and reporting. Whether you’re searching for single or multiple targets, AxION Solo allows you to take the fast, easy way to clear, confident analytical results.

PDF 228 KB

海报

Analysis of Impurities in Melatonin by LC/TOF-MS

幸运8平台彩票Melatonin is a hormone secreted by the brain to help regulate sleep. Since melatonin is found in certain foods, it can be sold as a dietary “over-the-counter” (OTC) supplement.

PDF 270 KB
Confirmation of drugs of abuse in pseudo drug mixes using UHPLC-ESI TOF MS

幸运8平台彩票Forensic crime labs are responsible for the qualitative confirmation of drugs of abuse for use in court cases. Gas chromatography mass spectrometry (GCMS) has been the gold standard for confirmation of cocaine, procaine, and morphine in confiscated illicit drugs.

PDF 224 KB