Angiotensin II, [125I]-Sar1, Ile8], 50µCi | PerkinElmer

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Angiotensin II, [125I]-Sar1, Ile8], 50µCi

Angiotensin II, labeled with 125I on the tyrosine residue. Angiotensin II is an endogenous agonist of angiotensin II receptors, a class of GPCRs important in vasoconstriction.

部件号 NEX248050UC
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详情 信息

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki幸运8平台彩票) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX248:

  1. Linares, A., Couling, L. E., Carrera, E. J., Speth, R. C. (2016), Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors. J. Vis. Exp. (112), e53866.
  2. Hwang, B.H., Chan, P., Peters, T. (2004), Angiotensin II receptor binding in the locus ceruleus of spontaneously hypertensive rats and Wistar-Kyoto rats: a quantitative autoradiographic study with references to hypertension and cardiac/testicular hypertrophy, J Biomed Sci, 11 (3): 331-338.

规格

检测方法 Radiometric
新鲜的很多天 Second Monday of each month
标签位置 Nominally Labeled
产品品牌名称 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受体类型 Angiotensin
运输条件 环境
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 Angiogenesis, Cardiovascular
产品尺寸 50 µCi
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Using the NENSure Packaging System from PerkinElmer

幸运8平台彩票Since 1985, the unique NENSure system has set the standard for radiochemical packaging. Based on proven performance over millions of shipments, the system provides: Ease of use, Safe storage of unused product and Reduced radiation exposure. Many NEN brand research products, including 32P-, 33P-, 35S-, 3H-, 14C- and 125I-labeled compounds, are packaged in the NENSure System, as are most radionuclides.

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