PerkinElmer

GPCR

OF

G蛋白偶联受体(GPCR)是结构变化多样的一大类蛋白膜受体,包括:β1和β2肾上腺素能受体、多巴胺能受体和胆碱能受体。我们可提供G蛋白偶联受体研究所需的所有先进检测分析设备。

以及多种靶标Gs-、Gq-和Gi-偶联受体的实验试剂。 我们产品还包括:

  • 荧光、发光或吸收光检测所需的可调焦GPCR细胞成像仪和液体工作站;
  • 经优化的GPCR细胞水平检测平台
  • 多样检测试剂——GPCR稳定表达细胞系、冷冻即用型GPCR细胞株及细胞膜制品,以及放射性配体等
  • 我们完备的产品组合能够满足GPCR研究的全部需求。您可借助以上仪器及试剂产品进行如下GPCR的研究应用:
  • GPCR通路激活研究:细胞内钙流、cAMP、磷酸化ERK,肌醇磷脂IP变化等
  • GPCR信号通路报告基因试验
  • 受体配体结合
  • GTP-γ-S结合活性

Receptor Cell Lines & Membranes

幸运8平台彩票Our selection of GPCR cell lines and membranes allows you to decrease your assay development time and increase the quality of your results. Our cell lines and membrane preparation are validated for optimal performance in both function and binding assays.

Radiolabeled Ligands

Receptor binding studies are an integral part of GPCR research. Our radioligand are all tested specifically for receptor binding during development. Furthermore, many of our GPCR related radioligands are used to QC our GPCR cell lines and membrane preparations.

For research and investigational use only.

LANCE cAMP

 

PerkinElmer's innovative LANCE® cAMP assay combines homogeneous TR-FRET technology with red-shifted Alexa®幸运8平台彩票 Fluor dye chemistry for maximum excitation/emission discrimination. The result is a FRET assay without the compound interference associated with blue dyes. You can read longer without accumulating background signal to maximize S/N and Z'.

AlphaLISA SureFire Ultra

This assay platform for the detection of phosphoproteins in simple to complex matrices serves as an excellent secondary technology for challenging targets and provides an alternative for tough-to-screen targets not optimally coupled through the calcium or cAMP pathway
产品与服务 (90)
Filters:

幸运8平台彩票 Filters :

应用
  • Drug Discovery & Development (40)
  • cAMP (8)
  • Kinase (5)
  • Protein Analysis & Detection (5)
  • Multiplexing (2)
检测点(200-50,000)
  • 50000 (10)
  • 10000 (10)
  • 500 (9)
  • 100 (2)
  • 1000 (1)
检测目标
  • Akt1/2/3 (4)
  • ERK1/2 (4)
  • cAMP (3)
  • Akt1 (2)
  • Akt1/2 (1)
  • CREB (1)
检测目标类
  • GPCR (55)
  • Phosphoprotein (11)
  • Protein (3)
检测验证
  • Binding (39)
  • Calcium Luminescence (25)
  • cAMP (5)
  • Downstream Phosphorylation (4)
  • Calcium Fluorescence (4)
自动化兼容
  • Yes (22)
浓度
  • 1.0 - 10 mCi/mL (2)
  • <1.0 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 1.12 mCi/mL (1)
  • 50 µCi/mL (1)
  • 83.8 µCi/mL (1)
检测方法
  • Alpha (12)
  • Radiometric (9)
  • Time-Resolved Fluorescence (TRF) (2)
  • TR-FRET (2)
实验类型
  • In vitro (11)
格式
  • Microplates (14)
宿主细胞
  • CHO-K1 (33)
  • HEK293 (26)
  • 1321N1 (2)
  • U373 (1)
  • L Cells (1)
  • UC11 (1)
  • HT29 (1)
  • A9 (1)
标签位置
  • Nominally Labeled (6)
  • Specifically Labeled (3)
分子修饰
  • Phosphorylation (7)
产品品牌名称
  • Membrane Target Systems (34)
  • AequoZen (16)
  • AequoScreen (9)
  • AlphaScreen SureFire (7)
  • NEN Radiolabeled Ligands (6)
  • cAMPZen (5)
  • NEN Radiochemicals (3)
  • AlphaLISA SureFire Ultra (3)
  • Alpha SureFire Ultra Multiplex (2)
  • AlphaPlex (2)
  • ValiScreen (2)
  • LANCE (1)
  • AlphaScreen (1)
  • LANCE Ultra (1)
放射性核素
  • 125I (6)
  • 3H (2)
放射性同位素
  • I-125 (6)
  • H-3 (2)
  • C-14 (1)
受体类型
  • Adenosine (13)
  • Opioid (10)
  • Adrenergic (5)
  • 5-Hydroxytryptamine (Serotonin) (4)
  • GABA (4)
  • Vasopressin (4)
  • 5-Hydroxytryptamine (2)
  • Melanocortin (2)
  • Neurotensin (2)
  • Melatonin (2)
  • Bradykinin (1)
  • Cannabinoid (1)
  • Calcitonin (1)
  • Glucagon (1)
  • Motilin (1)
  • Galanin (1)
  • Vasoactive Intestinal Peptide (1)
  • Prostanoid (1)
  • Anaphylatoxin (1)
  • Insulin (1)
  • Tachykinin (1)
  • Urotensin (1)
  • Histamine (1)
  • Dopamine (1)
目标种
  • Human (10)
治疗领域
  • Central Nervous System (33)
  • Inflammation (32)
  • Cardiovascular (29)
  • Metabolic (16)
  • Gastrointestinal (14)
  • Pain (13)
  • Diabetes (7)
  • Obesity (2)
  • Renal (2)
  • Angiogenesis (1)
  • CNS & Neurologic (1)

1-12 的 90 产品与服务

  • Jump to: