PerkinElmer

生物治疗

OF

幸运8平台彩票提供简单的工作流程解决方案,确保生物治疗研究和患者安全所需的一致、可复验结果。

幸运8平台彩票我们与世界领先的制药、生物技术、合同研究组织合作,协助研发制造新型药物和疫苗。我公司在以下领域具有丰富经验:

  • 抗体表征和测试
  • 靶标确认
  • 免疫原性/安全测试
  • 抗体筛选
  • 污染和质控测试
  • 细胞表征
  • 批次放行验证
  • 功能性测试
  • 疫苗研发
  • PK和功效试验

仅供研究使用。不适用于诊断程序。

Target Identification
Target Identification

靶标确定

在发现新生物治疗药物的早期阶段确定相关疾病标靶。彻底验证每个标靶,避免潜在的下游问题。我公司凭借试管和体内结合的方法,可提供最准确的标靶相关人类疾病的预测。
  • 试管标靶验证细胞成像
  • 标靶发现活体内成像
  • 活体外标靶验证组织成像
Protein Antibody
Protein Antibody

克隆和表达

我们提供一系列微流体、ELISA替代、成像、信息、检测和自动化解决方案,帮助您简化克隆和表达过程中各阶段的工作流程,提高生成的数据的质量:
  • 克隆选择
  • 蛋白质纯化
  • 功能筛选
  • 生物分析表征
General laboratory
General laboratory

临床前安全

通过高质量、可复验的测试数据,准确定量抗药物抗体(ADA)和药代动力学(PK)/药效学(PD)。无论您的研究涉及单克隆抗体(mAb)、蛋白质或多肽,我公司提供的多种免疫原性、中和抗体(NAb)和PD/PK测试解决方案均可帮助您简化工作流程。
Pipetting
Pipetting

生产和质控

确定过程和产品相关杂质,确保其不会影响生物治疗药物或疫苗研究的质量和安全性。

LabChip®微流体技术可对药用蛋白质进行快速可复验纯度分析,并可检测识别浓度峰值低至5ng/µL的低浓度杂质,从而加速生产和质控过程。

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1-12 的 186 产品与服务

  • FMT In Vivo Imaging Instrument

    FMT 2000 In Vivo Imaging System

    The FMT 2000 is a workhorse 3D fluorescence tomographic system with the ability to quantitate up to two fluorophores simultaneously.
  • FMT In Vivo Imaging Instrument

    FMT 4000 In Vivo Imaging System

    The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. It comes with four excitation laser channels (635, 680, 750, & 790 nm).
  • VictorX_ImageA_320px

    VICTOR 多模式读板仪

    新一代的 VICTOR X 系列多模式读板仪为各种规模的实验室提供集灵活性、高速度和高性能于一体的解决方案。
  • G8 PET/CT benchtop scanner for preclinical imaging research

    G8 PET/CT 成像系统集

    PerkinElmer 公司最新研发的 G8 PET/CT 二合一成像系统集成了高灵敏度 PET 成像及快速、低剂量 microCT 成像,使研究者在进行功能或代谢研究的同时,获取结构性图像数据。
  • 1000x1000_Opera_Phenix

    Opera Phenix 高内涵系统

    Opera Phenix™高内涵系统是目前最受期待的高内涵共聚焦技术方案。依赖将近20年的顶尖高内涵产品opera高内涵成像系统积累的丰富成像和应用经验,新一代的opera phenix系统系统专为高内涵表型筛选以及复杂的疾病模型量身打造,例如活细胞、原代细胞,细胞微组织。
  • EnSight Multimode Plate Reader

    EnSight 多模式读板仪

    EnSight 多模式读板仪是一台整合了多标记、无标记和显微成像技术的桌面式一体化检测平台。其整孔成像&在线数据分析速度非常快,可以在五分钟内完成384孔板整板的图像获取及分析。该仪器采用预置模块化设计,结合基于Kaleido软件的数据采集和分析流程,是一台真正的全能且高产的多模式读板仪。
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina LT 小动物活体成像系统

    IVIS® Lumina LT是PerkinElmer最新推出的第三代高灵敏度小动物活体光学二维成像平台。
  • FMT In Vivo Imaging Instrument

    FMT 1000 In Vivo Imaging System

    The FMT® 1000 is an entry level 3D fluorescence tomographic system with the ability to quantitate a single fluorophore at a time.
  • IVIS SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

    IVIS SpectrumCT 小动物活体成像系统

    IVIS® Spectrum CT是全球顶尖的小动物活体三维光学/CT二合一成像系统。
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS 小动物活体成像系统

    IVIS® Lumina XRMS III是PerkinElmer最新推出的二维多模式活体成像系统,具备最高灵敏度的生物发光、多光谱荧光、放射性同位素和X光活体成像功能。
  • IVIS Spectrum In Vivo Imaging System

    IVIS Spectrum 小动物活体成像系统

    IVIS® Spectrum 小动物活体光学成像系统是全球首台同时具备生物发光、荧光、化学发光及切伦科夫二维/三维成像功能的系统,代表了目前活体光学成像技术的最高水平。
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina III 小动物活体成像系统

    IVIS® Lumina III是PerkinElmer最新推出的第三代高灵敏度多光谱小动物活体光学二维成像平台。
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Business Insights (17)
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  • Application Note (12)
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1-12 的 17 Business Insights

  • 白皮书

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    幸运8平台彩票This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • 应用文献

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • 应用文献

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS™ high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony® software contribute to the robustness of the high-content assay.

  • 应用文献

    用高内涵筛选系统进行FRET测定

    幸运8平台彩票在这个实验中,我们建立了一种快速稳定的基于FRET的高内涵检测...

  • 应用文献

    NIR Fluorescent Cell Labeling for In Vivo Cell Tracking (VivoTrack 680)

    Fluorescent dyes have been used for many years to label cells for microscopy studies, and a variety of dyes in the visible fluorescence spectrum are available to label different cellular compartments and organelles. Efficient delivery of the fluorophore to the cell without excessively modifying surface proteins or perturbing cell function is the major biotechnological challenge. In addition, researchers have taken on the challenge of in vivo imaging, focusing on near infrared (NIR) dyes that fluoresce in a spectral region better suited for in vivo imaging due to reduced background and higher tissue penetration.

  • 应用文献

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    幸运8平台彩票Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • 应用文献

    Preclinical Fluorescence Imaging of Cancer Metastasis to the Lung and Response to Therapy

    Quantitative pre-clinical fluorescence imaging transcends the boundaries of traditional optical imaging of biological structures and physiology by providing information at the molecular level about disease states and therapeutic response. Fluorescent Pre-clinical Imaging Agents and FMT® (Fluorescence Molecular Tomography) Quantitative Pre-clinical Imaging Systems represent powerful tools for research and drug development in the imaging of biological processes and pharmaceutical activity in living animals.

  • 应用文献

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    幸运8平台彩票The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 应用文献

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    幸运8平台彩票Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 应用文献

    Stem Cell Research and Regenerative Medicine

    幸运8平台彩票With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • 应用文献

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • 应用文献

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

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